赵云峰简介

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赵云峰简介

赵云峰,男,博士,教授,硕士研究生导师。2005年在山东大学生命科学学院获理学博士学位。

多年来主持或参加国家或省部级科研课题10余项,主要研究方向为细胞生物学、肿瘤药物学,近年来主要在有机小分子化合物诱导肿瘤细胞凋亡与自噬、生物农药等方面进行研究。现主持国家自然科学基金1项(噻唑烷类化合物抗肿瘤作用及其作用机制研究, No. 31271475),青海省(应用)基础研究计划项目1项(瑞香狼毒黄酮类化合物与阿维菌素混配杀虫剂的研制);主持完成省级科研立项2项,厅级立项3项,横向项目2项;参与省部级以上项目4项。指导培养研究生20余名,现在读12名。近年来,在《Invest New Drugs》、《European Journal of Pharmacology》、《Chemico-Biological interaction》、《J Neural Transm》和《药学学报》等刊物上表论文40余篇,其中11篇被SCI收录。是《Invest New Drugs》、《Bioorganic & Medicinal Chemistry》、《Chemico-Biological interaction》等国际知名学术刊物的审稿人。主持《细胞生物学》校级精品课。1998年获山东省教委试验改进3等奖一次,2001年山东省教育厅科技进步3等奖一次。山东细胞学会常务理事,中国细胞学会会员,美国肿瘤学会会员,教育部专家库成员等。

主要研究兴趣:

1.有机小分子诱发的线粒体凋亡信号网络及肿瘤细胞凋亡/生存的分子机制。

2.有机小分子对内质网应急所诱导的细胞凋亡和肿瘤的调控研究。

3.新型高效生物农药菌株的育种研究。

4. 新型高效呼吸道兽药的研制。

代表性论文:

1. Zhao YF*, Zhang C, Suo YR. MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells. Eur J Pharmacol. 2012, 688(1-3):6-13. Epub 2012 May 17. (SCI)

2. Zhao YF*, Zhang N, Lu JM, Suo YR. Apoptosis induction by tetrazolium violet in H460 human lung cancer cells through reactive oxygen species production. Arch Pharm Res 2012 (accepted). (SCI)

3. Zhao YF*, Li XL, Sun YX, Niu W, Hu ZL Lin L. MMPT: a thiazolidin compound inhibits the growth of lung cancer H1792 cells via Fas-mediated and caspase-dependent apoptosis pathway. Invest New Drugs. 2010 June, 28(3):318-325. (SCI)

4. Zhao YF, Qing-Zhong Kong. Tetrazolium violet inhibits cell growth and induces cell death in C127 mouse breast tumor cells. Chemico-Biological interaction, 2008, July 10, 174(1):19-26. (SCI)

5. Zhao YF. 2,4-Dichloro-5-flurobenzoic acid, Acta Cryst. 2007.Des E63, 04449. (SCI)

6. Zhao YF, Nan Zhang and Qingzhong Kong. . Tetrazolium violet induces G0/G1 arrest and apoptosis in brain tumor cells. Journal of Neuro-Oncology. 2006, Apr 77, 109-115 SCI

7. Zhao YF, Nan Zhang, Qingzhong Kong. Does the cell-brain theory work in explaining carcinogenesis? Med Hypotheses. 2005, Oct 65, 708-815. (SCI)

8. Zhang XH, Zhang N, Lu JM, Kong QZ, Zhao YF*. Tetrazolium violet induced apoptosis and cell cycle arrest in human lung cancer A549 cells. Biomol Ther., 2012, 20(2), 177-182. (SCI)

9. Cai CF, Feng L, Wang L, Kong QZ, Zhao YF*. Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in Rat C6 glioma cells. Arch Pharm Res 2009, 32(4): 575-581. (SCI)

10. Kristin R. Landis-Piwowar , Vesna Milacic, Di Chen, Huanjie Yang, Zhao YF, Tak Hang Chan, Bing Yan, Q. Ping Dou. The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resistance Updates. 2006, Dec 9: 263-273. (SCI)

11. Qingzhong Kong, Nan Zhang, and Zhao YF. The roles of centrosome in cancer development. Drug News and Perspectives 2004, Apr 17,195. (SCI)

12. 秦咸蕴,林霖,杨燕,张书香,孔建强,程克棣, 赵云峰*,王伟*. EV71 非结构蛋白的结构和功能及其为靶点的药物研究进展. 药学学报,2011, 46 (7): 753-761.

13. 许芝山,朱凌云,王秀冬,赵云峰*,于爱平*.凝血酶体外促进肺癌细胞Glc-82周期进程和增殖及其分子机制.军事医学,2012,36(2):128-132.

联系方式:

曲阜师范大学生命科学学院,山东,曲阜,273165。

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